Figure 6

IL-6 production in supernatants from PVNS synovial tissue at different timepoints after Cd exposure. Supernatants from PVNS synovial tissues from three patients were collected at day 0, 1, 5, 10 and 14 after the treatment with 1 ppm of Cd with or without addition of the combination of pro-inflammatory cytokines (IL-17: 50 ng/ml and TNF: 1 ng/ml). IL-6 production was quantified by ELISA. Results are presented as mean ± SD. n = 3 from 3 PVNS synovial tissues.