Figure 4
Major druggable pockets around the hexamer interfaces. The table at the top shows the residues common to the pockets and are assigned as Pockets A‒C. The residue names shown in blue, red, and black indicate that they belong to N-term, Mid, or C-term domain, respectively. (a) Pockets A (green), (b) B (yellow), and (c) C (orange) identified for the monomer GM conformation. Druggable score of the pocket (Score) and pocket volume (V. unit: nm3) are shown. (d) UTP-binding pocket found in GM. (e‒g) The pockets most overlapped with pockets A‒C in apoH are depicted. (h) UTPH structure and 5′-UMP shown as a CPK model. Each domain is specified by a distinct color, as in Fig. 1a.
