Figure 3
From: An intra-cytoplasmic route for SARS-CoV-2 transmission unveiled by Helium-ion microscopy
Tunneling nanotube. The long TNT that connects cell A to B (named 1 and 2 in Fig. 2) interacts with at least three other cells along its path (B, C and D, in the top left inset). A mosaic reconstruction of HeIM micrographs (27,000×) highlights 8 notable events, some of which are magnified at a higher definition (×54,000). (1) Spherical bulging; (2) well defined spherical bulging and membrane fusion, in a region rich in mitochondria; (3) diameter enlargement by cargo content; (4) spherical bulging close to a (5) membrane fusion area; (6) well defined spherical bulging; (7) two close spherical bulging; (8) diameter enlargement. Higher definition micrographs show longitudinal cytoskeletal features under the membrane.
