Figure 2
From: miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy
Alterations in the liver transcriptome of mdx mice are affected by the additional lack of miR-378. (A) Transcriptome profiling by RNA-seq in the mdx vs. WT mice and mice lacking both dystrophin and miR-378 (mdx/miR-378−/−) vs. mdx segregates the investigated groups into 3 distinct clusters based on 1000 most variable genes, n = 4/group. (B) RNA-seq analysis revealed 561 DEGs between mdx vs. WT livers, and (C) 194 DEGs between mdx/miR-378−/− vs. mdx that distinguish the analyzed groups by principal component analysis (PCA) and hierarchical clustering.
