Figure 6
From: miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy
Disturbances in lipid metabolism in the liver of the mdx mice are affected by the additional lack of miR-378. (A) Ingenuity pathway analysis (IPA) revealed increased and decreased lipolysis in mdx vs. WT (p-value = 1.54 × 10–4) and mdx/miR-378−/− vs. mdx (p-value = 1.28 × 10−5) livers, respectively. (B) Incorporation of lipids was shown to be lower in the liver of mdx mice (p-value = 6.33 × 10–5) whereas the concentration of lipids was higher in mdx/miR-378−/− vs. mdx livers (p-value = 6.44 × 10–5). Triglyceride levels were assessed under non-fasting (fed) conditions and after overnight fasting (fasted) in (C) the serum; n = 5–6/group and (D) in the liver; 4–6/group. Data are presented as mean ± SEM. ***p < 0.001; ****p < 0.0001 by one-way ANOVA with Tukey’s post-hoc test.
