Table 2 Estimated effects of factors and interactions and their statistical significance in the screening DoE.

From: Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment

Factors

ATP content (× 106 RLU)

ATP/LDH ratio (× 106 RLU/ AU)

Insulin stimulation index

Estimated effect ± SD

p-value*

Estimated effect ± SD

p-value*

Estimated effect ± SD

p-value*

HEMOXCell (HEM)

1.68 ± 0.57

0.0109

1.52 ± 1.39

0.2928

0.38 ± 0.36

0.3160

Silicone-CaO2 (S-O2)

2.92 ± 0.57

0.0002

8.97 ± 1.39

< 10–4

0.81 ± 0.39

0.0633

O2 tension

2.05 ± 0.55

0.0027

4.11 ± 1.35

0.0095

1.61 ± 0.36

0.0013

HEM and S-O2 interaction

1.71 ± 0.57

0.0100

2.55 ± 1.39

0.0890

0.45 ± 0.36

0.2404

HEM and O2 tension interaction

0.63 ± 0.55

0.2788

0.91 ± 1.35

0.5152

0.45 ± 0.36

0.2380

S-O2 and O2 tension interaction

− 5.32 ± 0.55

< 10–4

0.42 ± 1.35

0.7630

− 0.15 ± 0.36

0.6838

  1. *p-values are computed from the analysis of variance performed for each response (Supplementary Tables 1–3). Statistical significance at 5% are highlighted in bold.
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