Table 3 Multi-response optimization for the screening DoE.

From: Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment

Optimization

Optimal level of factors

Response values at the optimum

HEMOXCell

Silicone-CaO2

O2 tension

ATP content (× 106 RLU)

ATP/LDH ratio (× 106 RLU/AU)

Insulin stimulation index

Optimization in hypoxia

w/

w/

Hypoxia

15.74

15.16

2.6

Back to article page