Figure 3 | Scientific Reports

Figure 3

From: A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis

Figure 3The alternative text for this image may have been generated using AI.

Comparison between groups during phase 2 of the trial regarding appropriateness and de-escalation of antimicrobial therapy. Analyses based on data of 29 participating hospitals. (a) Adjusted odds-ratios and p-values result from hierarchical generalized linear models with a logit link adjusted for the covariates age, sex, origin of infection, focus of infection, location at onset of infection and vasopressor use during the first 12 h. Since definitions of measures were changed between phases, no difference-in-difference analysis was possible. No. of patients gives the number of cases with complete data both on outcome and confounders compared to the total number of cases were the respective outcome was measured. Intraclass correlations (ICC): Appropriate initial antimicrobial therapy, ICC = 0.03; De-escalation within 5 days, ICC = 0.03. (b) Barplot on appropriateness of initial antimicrobial treatment. (c) Barplot on change of antimicrobial treatment within five days after sepsis onset.

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