Table 3 The top 10 significantly enriched GO terms for each of BPs, MFs and CCs with the hub-DEGs/proteins.

From: Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing

Source

GO term name

GO term id

Adj. p-value

Count

Associated hub DEGs or proteins

GO: MF

Protein binding

GO:0005515

0.0000

10

SNRPD2, ZFP36, NEDD9, KLF6, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Binding

GO:0005488

0.0001

10

SNRPD2, ZFP36, NEDD9, KLF6, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Molecular function

GO:0003674

0.0002

10

SNRPD2, ZFP36, NEDD9, KLF6, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Triacyl lipopeptide binding

GO:0042497

0.0049

1

TLR2

Protein-containing complex binding

GO:0044877

0.0185

3

IGF2, TLR2, GUCY1A2

Lipopolysaccharide immune receptor activity

GO:0001875

0.0185

1

TLR2

C–C chemokine binding

GO:0019957

0.0194

1

ZFP36

Lipopeptide binding

GO:0071723

0.0194

1

TLR2

NAD+ nucleotidase, cyclic ADP-ribose generating

GO:0061809

0.0194

1

TLR2

NAD+ nucleosidase activity

GO:0003953

0.0194

1

TLR2

GO: BP

Cellular response to lipopolysaccharide

GO:0071222

0.0009

3

ZFP36, TLR2, CXCL2

Immune system process

GO:0002376

0.0009

6

ZFP36, KLF6, IGF2, TLR2, PAG1, CXCL2

Positive regulation of cellular process

GO:0048522

0.0009

7

ZFP36, NEDD9, KLF6, IGF2, TLR2, PAG1, GUCY1A2

Biological regulation

GO:0065007

0.0009

9

ZFP36, NEDD9, KLF6, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Biological_process

GO:0008150

0.0009

10

SNRPD2, ZFP36, NEDD9, KLF6, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Cellular process

GO:0009987

0.0009

10

SNRPD2, ZFP36, NEDD9, KLF6, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Cellular response to molecule of bacterial origin

GO:0071219

0.0009

3

ZFP36, TLR2, CXCL2

Cellular response to biotic stimulus

GO:0071216

0.0010

3

ZFP36, TLR2, CXCL2

Signal transduction

GO:0007165

0.0011

7

ZFP36, NEDD9, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Response to stimulus

GO:0050896

0.0011

8

ZFP36, NEDD9, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

GO: CC

Cellular_component

GO:0005575

0.0005

10

SNRPD2, ZFP36, NEDD9, KLF6, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Cellular anatomical entity

GO:0110165

0.0005

10

SNRPD2, ZFP36, NEDD9, KLF6, USP53, IGF2, TLR2, PAG1, GUCY1A2, CXCL2

Dcp1–Dcp2 complex

GO:0098745

0.0066

1

ZFP36

Toll-like receptor 1-Toll-like receptor 2 protein complex

GO:0035354

0.0099

1

TLR2

cytoplasm

GO:0005737

0.0161

7

SNRPD2, ZFP36, NEDD9, KLF6, IGF2, TLR2, GUCY1A2

pICln-Sm protein complex

GO:0034715

0.0178

1

SNRPD2

Membrane raft

GO:0045121

0.0178

2

TLR2, PAG1

Membrane microdomain

GO:0098857

0.0178

2

TLR2, PAG1

RISC-loading complex

GO:0070578

0.0178

1

ZFP36

Membrane region

GO:0098589

0.0178

2

TLR2, PAG1

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