Figure 3
Multiple alignments of SYDE proteins. Color code is based on Clustalσ scheme and linear motifs are identified by ELM and D2P2 database Anchor definition22. (a) Alignment of SYDE1 and SYDE2. (b) Syde1 N-terminus and C-terminus. (c) Syde2 N-terminus and C-terminus. The signatures indicate: LIG_SH2_CRK/NCK: Crk and Nck SH2 domain binding motif; LIG_14-3-3; 14-3-3 binding motif; DOC_Cyclin_RxL: Cyclin/CDK binding motif; LIG_WW3: PPR-specific WW domain; DOC_MAPK: a docking motif for interaction with Erk1/2 and p38 subfamilies of MAP kinases; DOC_PP2B_LxvP1: calcineurin docking motif; DOC_PP4: a docking motif recognized by PP4 holoenzyme; MOD_CK1: CK1 phosphorylation site; MOD_CK2: CK2 phosphorylation site; MOD_GSK3: GSK3 phosphorylation recognition site; LIG_SH2_GRB2: Grb2-like SH2 binding motif; LIG_SH3_3: SH3 binding motif; DEG_SCF_FBW7: Phsopho-dependent degron recognized by FBW7 Fbox proteins; LIG_LIR_Gen1: LIR motif for ATG8-mediated autophagy.
