Figure 4
Overview of SYDE RhoGAP domains and structural RhoGAP models. (a) Consensus sequences of SYDE1 RhoGAP domains are shown in the panels. Secondary structures of human SYDE1 are indicated above the sequences (α-helix: gray column for SYDE1 and dark gray column for SYDE2; coiled-coil: gray dotted line) and α-helix of DmSyd1 is represented by horizonal orange line below the sequences. (b) Cartoons of SYDE RhoGAP domains are colored from the N-terminus (blue) to C-terminus (red). (c) Consensus sequences of SYDE C2 domains and secondary structures of human SYDE1/2 used for structure prediction are indicated above the sequences (β-sheet: gray column for SYDE1 and dark gray column for SYDE2). (d) Structure of SYDE C2 domains are colored from the N-terminus (blue) to C-terminus (red) by UCSF Chimera. The three-dimensional structures were visualized using UCSF Chimera software version 1.15 (http://www.cgl.ucsf.edu/chimera).
