Table 3 Relative abundance of individual metabolites in M.tb-stimulated whole blood QFT cultures.
Metabolite | Relative abundance | p value | Adjusted p value | ||
|---|---|---|---|---|---|
HC vs. TB | HC vs. LTBI | HC vs. NMP | |||
OFT TB1 culture | |||||
Leucine (Leu) | 2.546 | 0.926 | − 4.842 | 0.0002 | 0.006 |
Citrulline (Cit) | − 0.538 | − 0.760 | 1.863 | 0.0005 | 0.008 |
Kynurenine (Kyn) | 1.607 | 2.185 | − 0.537 | 0.001 | 0.011 |
Glutamine (Gln) | − 5.745 | − 1.186 | 8.638 | 0.004 | 0.030 |
Valine (Val) | − 3.535 | 0.756 | − 6.999 | 0.008 | 0.051 |
Hydroxyproline (Hyp) | − 1.734 | − 0.844 | − 1.807 | 0.014 | 0.071 |
Asparagine (Asn) | 1.068 | − 0.591 | 3.616 | 0.019 | 0.085 |
Pyroglutamic acid (Glp) | − 5.098 | 5.937 | − 16.195 | 0.113 | 0.388 |
Glycine (Gly) | 1.599 | 5.251 | − 2.551 | 0.128 | 0.388 |
Tyrosine (Tyr) | − 0.656 | − 1.261 | 1.507 | 0.129 | 0.388 |
Tryptophan (Trp) | − 2.049 | − 2.432 | − 4.730 | 0.181 | 0.495 |
Cysteine (Cys) | 12.573 | − 4.014 | − 16.062 | 0.207 | 0.519 |
Glutathione (GSH) | − 5.396 | − 10.880 | 80.278 | 0.265 | 0.613 |
Threonine (Thr) | 8.288 | 11.717 | − 45.299 | 0.310 | 0.666 |
Para-aminobenzoic acid (PABA) | − 5.494 | − 5.937 | 8.398 | 0.337 | 0.674 |
Gamma-aminobutyric acid (GABA) | − 0.140 | − 0.152 | − 0.346 | 0.388 | 0.727 |
Methionine (Met) | 0.616 | 0.093 | − 0.277 | 0.436 | 0.770 |
Lysine (Lys) | − 0.303 | 0.216 | 3.012 | 0.477 | 0.796 |
Phenyloalanine (Phe) | 4.541 | 1.442 | − 1.869 | 0.567 | 0.882 |
Neopterin (Neo) | − 0.415 | 0.577 | − 1.064 | 0.600 | 0.882 |
Inosine (Ino) | 0.032 | 0.162 | 0.037 | 0.617 | 0.882 |
Glycyl-L-valine | − 0.052 | 0.157 | − 0.185 | 0.674 | 0.919 |
Alanine (Ala) | − 4.594 | − 2.091 | − 5.405 | 0.775 | 0.999 |
Proline (Pro) | 1.624 | 0.734 | 1.981 | 0.839 | 0.999 |
Serine (Ser) | 0.715 | − 0.001 | − 1.120 | 0.853 | 0.999 |
Isoleucine (Ile) | 0.502 | 0.089 | − 0.077 | 0.966 | 0.999 |
Cystine | − 0.002 | − 0.002 | − 0.002 | 0.972 | 0.999 |
Arginine (Arg) | − 0.00001 | − 0.00001 | 0.00008 | 0.999 | 0.999 |
Pyridoxal | − 0.00001 | − 0.00001 | 0.00008 | 0.999 | 0.999 |
Isopyridoxal | − 0.00001 | − 0.00001 | 0.00008 | 0.999 | 0.999 |
OFT TB2 culture | |||||
Kynurenine (Kyn) | 1.153 | 2.069 | − 1.660 | 0.001 | 0.021 |
Citrulline (Cit) | − 0.562 | − 0.800 | 1.604 | 0.001 | 0.021 |
Valine (Val) | − 4.365 | 0.372 | − 7.432 | 0.002 | 0.021 |
Cysteine (Cys) | 27.097 | − 1.143 | − 16.903 | 0.013 | 0.077 |
Glutamine (Gln) | − 3.741 | 0.750 | 10.006 | 0.013 | 0.077 |
Asparagine (Asn) | 0.400 | − 0.820 | 2.905 | 0.015 | 0.077 |
Leucine (Leu) | 1.088 | 1.294 | − 3.637 | 0.019 | 0.085 |
Hydroxyproline (Hyp) | − 1.784 | − 0.771 | − 1.519 | 0.022 | 0.085 |
Tyrosine (Tyr) | − 0.546 | − 1.178 | 2.601 | 0.029 | 0.098 |
Pyroglutamic acid (Glp) | − 4.660 | 2.218 | − 14.397 | 0.038 | 0.115 |
Proline (Pro) | 3.136 | 0.538 | 5.688 | 0.134 | 0.366 |
Glycyl-L-valine | 0.172 | 0.241 | − 0.283 | 0.196 | 0.492 |
Isoleucine (Ile) | 1.865 | 0.197 | − 0.727 | 0.241 | 0.511 |
Tryptophan (Trp) | − 1.625 | − 0.923 | − 4.933 | 0.246 | 0.511 |
Glutathione (GSH) | − 19.713 | − 16.311 | 65.044 | 0.258 | 0.511 |
Methionine (Met) | 0.818 | 0.047 | 0.164 | 0.272 | 0.511 |
Threonine (Thr) | − 11.768 | 12.204 | − 38.171 | 0.308 | 0.544 |
Para-aminobenzoic acid (PABA) | − 5.045 | − 5.524 | 7.459 | 0.364 | 0.607 |
Glycine (Gly) | 6.974 | 2.853 | − 0.150 | 0.394 | 0.622 |
Neopterin (Neo) | − 0.453 | 0.659 | − 1.409 | 0.519 | 0.779 |
Lysine (Lys) | 2.112 | 0.218 | 1.581 | 0.551 | 0.787 |
Phenyloalanine (Phe) | 4.061 | 2.007 | − 1.519 | 0.597 | 0.815 |
Inosine (Ino) | − 0.059 | 0.110 | 0.027 | 0.738 | 0.936 |
Gamma-aminobutyric acid (GABA) | − 0.052 | − 0.106 | − 0.288 | 0.749 | 0.936 |
Alanine (Ala) | 4.660 | 1.764 | − 3.009 | 0.797 | 0.945 |
Serine (Ser) | 0.822 | 0.022 | − 1.066 | 0.819 | 0.945 |
Arginine (Arg) | − 0.005 | − 0.005 | − 0.005 | 0.933 | 0.999 |
Cystine | − 0.0007 | − 0.0008 | 0.002 | 0.982 | 0.999 |
Pyridoxal | 0.0001 | 0.000001 | 0.00003 | 0.999 | 0.999 |
Isopyridoxal | 0.0001 | 0.000001 | 0.00003 | 0.999 | 0.999 |
