Table 4 Results of the ROC analyses of metabolites measured in sera.

Metabolite	AUC
Metabolite	HC vs TB + LTBI + NMP	TB vs. LTBI + NMP + HC	TB + LTBI vs HC + NMP	TB + NMP vs HC + LTBI
Lysine (Lys)	0.556	0.581	0.594	0.594
Arginine (Arg)	0.515	0.544	0.499	0.507
Cystine	0.530	0.482	0.541	0.496
Asparagine (Asn)	0.600	0.602	0.570	0.482
Glycine (Gly)	0.553	0.540	0.571	0.538
Serine (Ser)	0.538	0.496	0.544	0.499
Alanine (Ala)	0.532	0.521	0.550	0.487
Glutamine (Gln)	0.503	0.681	0.557	0.503
Hydroxyproline (Hyp)	0.490	0.607	0.525	0.616
Threonine (Thr)	0.500	0.663	0.546	0.504
Cysteine (Cys)	0.530	0.570	0.511	0.573
Proline (Pro)	0.552	0.506	0.521	0.558
Valine (Val)	0.537	0.556	0.589	0.607
Methionine (Met)	0.559	0.567	0.574	0.547
Tyrosine (Tyr)	0.578	0.525	0.473	0.588
Leucine (Leu)	0.549	0.474	0.620	0.622
Isoleucine (Ile)	0.557	0.525	0.607	0.584
Phenyloalanine (Phe)	0.524	0.514	0.561	0.563
Tryptophan (Trp)	0.521	0.580	0.503	0.574
Glutathione (GSH)	0.532	0.469	0.519	0.544
Gamma-aminobutyric acid (GABA)	0.590	0.472	0.596	0.505
Para-aminobenzoic acid (PABA)	0.519	0.569	0.593	0.584
Kynurenine (Kyn)	0.526	0.545	0.510	0.556
Inosine (Ino)	0.500	0.623	0.474	0.480
Citrulline (Cit)	0.479	0.540	0.420	0.573
Neopterin (Neo)	0.506	0.554	0.527	0.561
Pyridoxal	0.500	0.500	0.500	0.500
Pyroglutamic acid (Glp)	0.497	0.626	0.521	0.605
Isopyridoxal	0.500	0.500	0.500	0.500
Glycyl-L-valine	0.536	0.545	0.552	0.504

AUC area under curve, HC M.tb-uninfected healthy controls, LTBI latently M.tb infected individuals, NMP patients with nonmycobacterial pneumonia, TB active tuberculosis patients.

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