Table 5 Results of the ROC analyses of metabolites measured in M.tb-stimulated whole blood QFT cultures.

From: Targeted metabolomics analysis of serum and Mycobacterium tuberculosis antigen-stimulated blood cultures of pediatric patients with active and latent tuberculosis

Metabolite	AUC
Metabolite	HC vs TB + LTBI + NMP	TB vs. LTBI + NMP + HC	TB + LTBI vs. HC + NMP	TB + NMP vs. HC + LTBI
OFT TB1 culture
Lysine (Lys)	0.494	0.535	0.548	0.587
Arginine (Arg)	0.500	0.500	0.500	0.500
Cystine	0.496	0.502	0.496	0.497
Asparagine (Asn)	0.522	0.511	0.510	0.563
Glycine (Gly)	0.556	0.522	0.570	0.522
Serine (Ser)	0.515	0.499	0.531	0.477
Alanine (Ala)	0.504	0.539	0.518	0.542
Glutamine (Gln)	0.536	0.581	0.476	0.565
Hydroxyproline (Hyp)	0.552	0.727	0.522	0.749
Threonine (Thr)	0.509	0.610	0.492	0.562
Cysteine (Cys)	0.511	0.567	0.505	0.546
Proline (Pro)	0.586	0.597	0.474	0.666
Valine (Val)	0.518	0.573	0.487	0.593
Methionine (Met)	0.546	0.655	0.573	0.545
Tyrosine (Tyr)	0.508	0.546	0.524	0.468
Leucine (Leu)	0.532	0.461	0.590	0.567
Isoleucine (Ile)	0.569	0.564	0.578	0.531
Phenyloalanine (Phe)	0.546	0.483	0.569	0.519
Tryptophan (Trp)	0.518	0.549	0.496	0.553
Glutathione (GSH)	0.509	0.507	0.473	0.558
Gamma-aminobutyric acid (GABA)	0.592	0.562	0.538	0.640
Para-aminobenzoic acid (PABA)	0.557	0.547	0.622	0.570
Kynurenine (Kyn)	0.638	0.508	0.717	0.595
Inosine (Ino)	0.587	0.573	0.537	0.563
Citrulline (Cit)	0.491	0.530	0.432	0.578
Neopterin (Neo)	0.511	0.553	0.517	0.534
Pyridoxal	0.500	0.500	0.500	0.500
Pyroglutamic acid (Glp)	0.510	0.579	0.474	0.601
Isopyridoxal	0.500	0.500	0.500	0.500
Glycyl-L-valine	0.503	0.593	0.504	0.546
OFT TB2 culture
Lysine (Lys)	0.492	0.529	0.542	0.570
Arginine (Arg)	0.496	0.502	0.496	0.497
Cystine	0.498	0.507	0.489	0.510
Asparagine (Asn)	0.511	0.564	0.570	0.563
Glycine (Gly)	0.577	0.585	0.581	0.552
Serine (Ser)	0.501	0.502	0.516	0.473
Alanine (Ala)	0.507	0.528	0.519	0.466
Glutamine (Gln)	0.506	0.584	0.555	0.561
Hydroxyproline (Hyp)	0.563	0.728	0.514	0.757
Threonine (Thr)	0.531	0.502	0.559	0.537
Cysteine (Cys)	0.531	0.584	0.534	0.454
Proline (Pro)	0.560	0.608	0.497	0.671
Valine (Val)	0.543	0.578	0.511	0.601
Methionine (Met)	0.548	0.629	0.558	0.559
Tyrosine (Tyr)	0.518	0.532	0.522	0.555
Leucine (Leu)	0.531	0.475	0.585	0.570
Isoleucine (Ile)	0.539	0.554	0.541	0.531
Phenyloalanine (Phe)	0.531	0.546	0.555	0.508
Tryptophan (Trp)	0.529	0.565	0.492	0.576
Glutathione (GSH)	0.497	0.524	0.465	0.540
Gamma-aminobutyric acid (GABA)	0.602	0.637	0.576	0.634
Para-aminobenzoic acid (PABA)	0.564	0.547	0.636	0.581
Kynurenine (Kyn)	0.609	0.525	0.688	0.594
Inosine (Ino)	0.545	0.578	0.505	0.535
Citrulline (Cit)	0.484	0.525	0.425	0.582
Neopterin (Neo)	0.504	0.431	0.512	0.547
Pyridoxal	0.500	0.500	0.500	0.500
Pyroglutamic acid (Glp)	0.509	0.598	0.542	0.603
Isopyridoxal	0.500	0.500	0.500	0.500
Glycyl-L-valine	0.535	0.605	0.480	0.587

AUC area under curve, HC M.tb-uninfected healthy controls, LTBI latently M.tb infected individuals, NMP patients with nonmycobacterial pneumonia, TB active tuberculosis patients.

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Table 5 Results of the ROC analyses of metabolites measured in M.tb-stimulated whole blood QFT cultures.

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