Table 3 Activity profile of the 3,3-difluoro-2-azetidinone (DFA) against H37Rv-GFP, in presence or absence of PAS.

From: A combination screening to identify enhancers of para-aminosalicylic acid against Mycobacterium tuberculosis

Compound

IC50 (μM)a

Ln(FC)

Category

Untreated

PAS-treated

DFA_1

NA

7.5 (3.6–16.0)

–

Additive

DFA_2

NA

6.4 (5.5–7.3)

–

Additive

DFA_3

NA

8.0 (6.7–9.5)

–

Additive

DFA_4

NA

14.4 (no plateau)

–

Additive

DFA_5

NA

4.8 (2.8–8.3)

–

Additive

DFA_6

NA

9.5 (7.7–11.8)

–

Additive

  1. aValues are best-fit for a duplicated dose–response. The 95% CI is indicated in parenthesis, except for cases where it was very wide (no plateau for the bottom value of the curve). NA: not active or IC50 > 25 μM.
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