Table 4 Activity profile of the purine-like (PL) derivatives against H37Rv-GFP, in presence or absence of PAS.

From: A combination screening to identify enhancers of para-aminosalicylic acid against Mycobacterium tuberculosis

Compound

IC50 (μM)a

Ln(FC)

Category

Untreated

PAS-treated

PL_1

NA

7.6 (6.4–9.0)

–

Additive

PL_2

NA

3.5 (3.2–4.0)

–

Additive

PL_3

NA

10.3 (no plateau)

–

Additive

PL_4

8.7 (5.9–12.8)

4.8 (4.3–5.4)

0.59

Additive

PL_5

NA

23.2 (no plateau)

–

Additive

PL_6

8.4 (5.5–12.7)

4.8 (4.2–5.5)

0.56

Additive

  1. aValues are best-fit for a duplicated dose–response. The 95% CI is indicated in parenthesis, except for cases where it was very wide (no plateau for the bottom value of the curve). NA: not active or IC50 > 25 μM.
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