Figure 4
From: Natural antibodies and CRP drive anaphylatoxin production by urate crystals
CRP drives anaphylatoxin production in the presence of MSU crystals. IgM/IgA-deficient serum obtained from 3 individuals with CVID was depleted of CRP and then reconstituted with vehicle or CRP at 10 or 30 µg/ml. The serum samples were incubated for 30 min with nothing, MSU lot 2, or cholesterol crystals. The concentrations of anaphylatoxins C4a, C3a, and C5a in the serum after the incubation are shown. p values are shown for the comparison of the means of vehicle, 10 µg/ml CRP, and 30 µg/ml CRP as determined by one-way repeated-measures ANOVA.
