Figure 6
Loss of lysophosphatidic acid receptor 4 increases abdominal aortic aneurysm formation. (A) Plasma cholesterol at baseline and post-1 week AngII were measured in WT (n = 5) and LPAR4Y/− (n = 6) mice, *P < 0.001 Two way ANOVA, Bonferroni t-test, all pairwise multiple comparison. (B) Abdominal aortic diameter measurements of WT (n = 5) and LPAR4Y/− (n = 6) were measured using ultrasound at baseline and 1 week AngII. *P < 0.05, Two way ANOVA, Holm-Sidak, all pairwise multiple comparison. (C) Percent mortality of WT (n = 16) and LPAR4Y/− (n = 20) mice within one week of treatment with AngII; P = 0.026 by Fisher’s exact test.
