Table 4 GO term enrichment results of all differentially expressed genes using IPA within each breed.
Breed | Category | Module | Functions | z-score† | Adjusted p value | Predicted action | Involved genes |
|---|---|---|---|---|---|---|---|
ANG | Organismal survival | 17 | Organismal death | 3.527 | 0.000 | Activated | BMP7,CFB,CXCL14,EPHB2,HAS2,ITGA11,MYB,PDPN,PERP,PLAU,PTHLH,ROR1,SFRP4,SYCP3,TH,THBD,WNT2 |
18 | Morbidity or mortality | 3.285 | 0.000 | Activated | BMP7,CFB,CXCL14,EPHB2,HAS2,ITGA11,MYB,PDPN,PERP,PLAU,PTHLH,RASSF5,ROR1,SFRP4,SYCP3,TH,THBD,WNT2 | ||
6 | Perinatal death | 2.421 | 0.005 | Activated | BMP7,CXCL14,PDPN,PTHLH,TH,WNT2 | ||
Organismal injury and abnormalities | 5 | Edema | 2.000 | 0.003 | Activated | HAS2,PDPN,PLAU,ROR1,TNFAIP6 | |
Cell signaling, molecular transport, vitamin and mineral metabolism | 5 | Quantity of Ca2+ | −2.143 | 0.004 | Inhibited | ACKR2,NTS,PLAU,PTHLH,TPSAB1/TPSB2 | |
Cellular development, cellular growth and proliferation | 6 | Cell proliferation of breast cancer cell lines | −2.168 | 0.002 | Inhibited | BMP7,HAS2,MYB,PLAU,PTHLH,SMPD3 | |
Carbohydrate metabolism | 7 | Metabolism of carbohydrate | −2.173 | 0.001 | Inhibited | BMP7,GFPT2,HAS2,NTS,PLAU,THBD,TNFAIP6 | |
6 | Synthesis of carbohydrate | −2.191 | 0.001 | Inhibited | BMP7,HAS2,NTS,PLAU,THBD,TNFAIP6 | ||
Cellular movement | 12 | Cell movement of tumor cell lines | −2.182 | 0.000 | Inhibited | BMP7,CXCL14,EPHB2,HAS2,MYB,PDPN,PLAU,PTHLH,ROR1,SFRP4,THBD,TIAM1 | |
5 | Invasion of breast cancer cell lines | −2.183 | 0.001 | Inhibited | HAS2,MYB,PLAU,ROR1,TIAM1 | ||
8 | Migration of tumor cell lines | −2.235 | 0.001 | Inhibited | EPHB2,HAS2,PDPN,PLAU,PTHLH,ROR1,SFRP4,TIAM1 | ||
19 | Migration of cells | −3.475 | 0.000 | Inhibited | ACKR2,BMP7,CFB,CXCL14,EPHB2,HAS2,HDC,MYB,NTS,PDPN,PLAU,PTHLH,RASSF5,ROR1,SFRP4,THBD,TIAM1,TNFAIP6,TPSAB1/TPSB2 | ||
20 | Cell movement | −3.747 | 0.000 | Inhibited | ACKR2,BMP7,CFB,CXCL14,EPHB2,HAS2,HDC,ITGA11,MYB,NTS,PDPN,PLAU,PTHLH,RASSF5,ROR1,SFRP4,THBD,TIAM1,TNFAIP6,TPSAB1/TPSB2 | ||
Cell-to-cell signaling and interaction | 6 | Aggregation of cells | −2.183 | 0.000 | Inhibited | BMP7,HDC,PDPN,PTHLH,THBD,WNT2 | |
Molecular transport | 6 | Quantity of metal | −2.348 | 0.002 | Inhibited | ACKR2,AP3B2,NTS,PLAU,PTHLH,TPSAB1/TPSB2 | |
Cellular movement, hematological system development and function, immune cell trafficking | 11 | Cell movement of leukocytes | −2.571 | 0.000 | Inhibited | ACKR2,CFB,CXCL14,HDC,MYB,PDPN,PLAU,RASSF5,THBD,TIAM1,TPSAB1/TPSB2 | |
Cellular assembly and organization, cellular function and maintenance | 10 | Microtubule dynamics | −2.706 | 0.002 | Inhibited | BMP7,EPHB2,HAS2,MYB,NTS,PDPN,PLAU,ROR1,THBD,TIAM1 | |
11 | Organization of cytoskeleton | −2.861 | 0.002 | Inhibited | BMP7,EPHB2,HAS2,MYB,NTS,PDPN,PLAU,RASSF5,ROR1,THBD,TIAM1 | ||
Organismal development | 8 | Size of body | −2.781 | 0.002 | Inhibited | BMP7,CXCL14,ITGA11,PLAU,SFRP4,SMPD3,TH,WNT2 | |
CHAR | Infectious diseases | 5 | Infection of mammalia | 2.190 | 0.000 | Activated | ASGR1,CAMP,IGHM,PLAU,STX11 |
KC | Energy production | 6 | Consumption of oxygen | 2.449 | 0.004 | Activated | ETFBKMT,G0S2,LEPR,SERPINE1,SLC25A25,SLC2A1 |
Cell death and survival, embryonic development | 5 | Apoptosis of embryonic cells | 2.236 | 0.001 | Activated | ACVR1C,ALX3,DOT1L,ITGA5,SLC2A1 | |
Endocrine system development and function, molecular transport, small molecule biochemistry | 10 | Concentration of hormone | −2.146 | 0.005 | Inhibited | DUOXA2,FSTL3,LDLR,LEPR,PDK4,SMPD3,TLR5,TNFRSF12A,TTR,WNK4 | |
Connective tissue development and function, tissue morphology | 20 | Quantity of connective tissue | −2.298 | 0.000 | Inhibited | CIDEA,CLEC10A,CXCL8,DLK1,FSTL3,FZD9,G0S2,LDLR,LEPR,MFSD2A,NFATC2,PDK4,SERPINE1,SLC20A1,SLC25A25,SLC7A1,SOST,SREBF1,TLR5,TNFSF10 | |
Lipid metabolism, molecular transport, small molecule biochemistry | 11 | Concentration of triacylglycerol | −2.319 | 0.000 | Inhibited | ACLY,CIDEA,DLK1,G0S2,LDLR,LEPR,MFSD2A,PDK4,SERPINE1,SREBF1,TLR5 | |
Nutritional disease | 17 | Obesity | −2.531 | 0.000 | Inhibited | CCRL2,CHRNA1,CIDEA,CXCL8,DLK1,G0S2,LDLR,LEPR,MFSD2A,PDK4,PROX1,SCN11A,SCN3A,SERPINE1,SLC25A25,SREBF1,TLR5 |
