Table 5 Predicted function of differentially expressed (DE) genes in subcutaneous adipose tissue of involved in the predicted lipid metabolic function using IPA.

From: Breed dependent regulatory mechanisms of beneficial and non-beneficial fatty acid profiles in subcutaneous adipose tissue in cattle with divergent feed efficiency

Predicted functions

z-score†

DE gene*

Gene description

log2FC#

Adjusted P value

Location

Concentration of triacylglycerol

(KC)

−2.319

DLK1

delta like non-canonical Notch ligand 1

2.474

0.002

Plasma Membrane

LEPR

leptin receptor

2.057

0.024

Membrane

TLR5

toll like receptor 5

1.617

0.012

Plasma Membrane

PDK4

pyruvate dehydrogenase kinase 4

1.230

0.046

Cytoplasm

ACLY

ATP citrate lyase

−1.364

0.045

Cytoplasm

CIDEA

cell death-inducing DFFA-like effector a

−1.012

0.017

Cytoplasm

G0S2

G0/G1 switch 2

−1.583

0.013

Cytoplasm

LDLR

low density lipoprotein receptor

−1.653

 < 0.001

Plasma Membrane

MFSD2A

major facilitator superfamily domain containing 2A

−1.611

0.046

Plasma Membrane

SERPINE1

serpin family E member 1

−1.464

0.001

Extracellular Space

SREBF1

sterol regulatory element binding transcription factor 1

−1.140

 < 0.001

Nucleus

  1. †z-score ≥ 2 and z-score ≤ − 2 indicate Activated and Inhibited activation state.
  2. *Differentially expressed genes were based on pairwise comparison between H- and L-RFIfat with FDR ≤ 0.1 and |log2FC|≥ 1 as cut-off.
  3. #Log2FC ≥ 1 and log2FC ≤  − 1 indicate up- and down-regulation of a gene in L-RFIfat compared to H-RFIfat steers, respectively.
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