Figure 3 | Scientific Reports

Figure 3

From: Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways

Figure 3

LS occurs during fasting in TXNIP-KO mice. LS during the fasted state in TXNIP-KO mice was verified by H&E, Oil Red O and PAS staining. Prominent hepatic microvesicular steatosis with enlarged nuclei (arrows) was observed in livers of TXNIP-KO mice in the fasted state by H&E staining, and accumulation of lipid droplets was detected by Oil Red O staining (scale bar = 50 μm). PAS staining showed depletion of glycogen in livers of fasted TXNIP-KO mice: depletion of glycogen was found even in the fed state. Representative photographs from each group are shown (six mice per group). H&E hematoxylin–eosin, PAS periodic acid Schiff, TXNIP thioredoxin-interacting protein, WT wild-type mice, KO knockout mice.

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