Figure 3
From: Glyoxylate protects against cyanide toxicity through metabolic modulation
Oxygen metabolism is restored following glyoxylate treatment. (A) Oxygen consumption rates of 5 dpf zebrafish treated with DMSO, KCN, or KCN and glyoxylate with the given concentrations (**p < 0.005 using one-way ANOVA). Fish were arrayed 1 per well, N = 4 wells for each condition. (B) Glyoxylate was given i.m. to rabbits 30 min after exposure to i.v. cyanide, and deoxygenated and oxygenated hemoglobin were monitored throughout the timecourse with diffuse optical spectroscopy (DOS). Data from a single representative rabbit are shown. (C) DOS monitoring of cytochrome C oxidase state. Glyoxylate was administered i.m. 30 min after i.v. cyanide infusion started. Results shown for a single rabbit are typical of the response seen by DOS in animals treated with cyanide and glyoxylate.
