Table 1 Agreement between proposed Synthetic Boolean model and experimental data from the literature in HeLa cells.
Stimulus/perturbations | Response/phenotype | References |
|---|---|---|
Transfection of miR-16 | Induction of autophagy, apoptosis and senescence | |
Knockdown (KO) of mTORC2 | Autophagy | |
Knockdown (KO) of mTORC1 | Induction of autophagy, apoptosis and senescence | |
Transfection of miR-449a | Induction of apoptosis and senescence | |
Transfection of miR-34a | Induction of apoptosis and senescence | |
Knockdown (KO) of PACS1 | Induction of apoptosis and senescence | |
Synergistic regulation between miR-34 E1 and miR-449a E1 | Induction of senescence, autophagy and apoptosis | ? |
Synergistic regulation between miR-16 E1 and miR-449a E1 | Induction of autophagy, apoptosis and senescence | ? |
Synergistically overexpression (E1) of miR-449a/miR-34a/miR-16 | Inhibits proliferation on the functional and stable G1/S checkpoint | ? |
Targeting of Cdc25A by miR-16/miR-34a/miR-449a | Repression of proliferation through the induction of DNA Damage Response pathways | ? |
Knockdown (KO) of PACS1 | Repression of proliferation through the induction of autophagy along with apoptosis and senescence | ? |
Transfection of miR-34a | Inhibition of proliferation and induction of senescence, autophagy and apoptosis | ? |
