Figure 1 | Scientific Reports

Figure 1

From: Revealing key lncRNAs in cytogenetically normal acute myeloid leukemia by reconstruction of the lncRNA–miRNA–mRNA network

Figure 1

The flowchart for reconstruction of the lncRNA–miRNA–mRNA network. First, miRNA/lncRNA/mRNA expression data were downloaded from NCBI GEO. Second, differentially expressed miRNAs (DEmiRNAs), lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) were screened. Third, target mRNAs of DEmiRNAs were predicted using miRDB, miRTarBase and TargetScan databases. And target lncRNAs of DEmiRNAs were predicted using starbase database. Then, DElncRNAs and DEmRNAs were merged with the target lncRNAs and mRNAs of DEmiRNAs, respectively. The co-expression lncRNAs and mRNAs were selected. Finally, the DEmiRNAs, co-expression lncRNAs and mRNAs were mapped into the interactions.

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