Figure 1 | Scientific Reports

Figure 1

From: Comparisons of plasma and fecal pharmacokinetics of danofloxacin and enrofloxacin in healthy and Mannheimia haemolytica infected calves

Figure 1The alternative text for this image may have been generated using AI.

Concentration versus time plot of danofloxacin (A DAN in plasma, B DAN in feces), enrofloxacin (C ENR in plasma, E ENR in feces) and ciprofloxacin (D CIP in plasma, F CIP in feces) in plasma and feces. The concentrations depicted in the graphs were the mean of all calves in a group at a given sampling time with the standard error (mean ± SE). None of the considered PK parameters were significantly different between healthy and BRD calves in plasma data, while some of the PK parameters derived from the fecal data (i.e., B) were significantly different. Groups study 1 (Panels A and B): Control—healthy calves injected danofloxacin (DAN, 8 mg/kg, n = 10) and BRD—calves infected with M. haemolytica and injected danofloxacin (DAN, 8 mg/kg, n = 10); study 2 (C–F): High-BRD—calves infected with M. haemolytica and injected high dose enrofloxacin (ENR, 12.5 mg/kg, n = 7), High-Control—healthy calves injected high dose enrofloxacin (ENR, 12.5 mg/kg, n = 7), Low-BRD—calves infected with M. haemolytica and injected low dose enrofloxacin (ENR, 7.5 mg/kg, n = 7), and Low-Control—healthy calves injected low dose enrofloxacin (ENR, 7.5 mg/kg, n = 7).

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