Table 1 The plasma pharmacokinetic parameters of danofloxacin administered to calves subcutaneously (8 mg/kg body weight, ten animals in each group) computed by a non-compartmental (i.e., statistical moments) analysis.

From: Comparisons of plasma and fecal pharmacokinetics of danofloxacin and enrofloxacin in healthy and Mannheimia haemolytica infected calves

Parameters*

Group

Minimum

Median

Maximum

Adjusted P-value**

AUCinf (h × μg/mL)

Control

13.3

23.0

29.9

0.968

BRD

12.8

22.8

27.0

AUCinf/Dose

Control

1.66

2.87

3.73

0.968

BRD

1.60

2.85

3.37

AUC0~48 (h × μg/mL)

Control

12.7

22.2

29.2

0.905

BRD

12.6

21.5

26.2

AUC0~48

/Dose

Control

1.61

2.77

3.65

0.9682

BRD

1.57

2.69

3.28

AUClast (h × μg/mL)

Control

12.5

21.4

28.3

0.842

BRD

12.2

20.9

25.6

AUMCinf (h2 × μg/mL)

Control

92.9

160.5

200.5

0.905

BRD

86.0

141.6

196.0

AUMClast (h2 × μg/mL)

Control

64.3

113.3

147.7

0.842

BRD

64.3

111.6

128.8

Cl/F (1/h)

Control

0.27

0.35

0.60

0.935

BRD

0.30

0.35

0.62

Cmax (μg/mL)

Control

2.5

4.8

5.6

0.838

BRD

2.4

4.6

6.1

Cmax /Dose

Control

0.3

0.6

0.7

0.838

BRD

0.3

0.58

0.8

T1/2 λz (h)

Control

7.5

8.2

8.8

0.842

BRD

6.5

7.7

10.6

λz (1/h)

Control

0.08

0.08

0.09

0.838

BRD

0.07

0.09

0.11

MRTinf (h)

Control

6.3

7.0

7.7

0.356

BRD

5.6

6.3

8.6

MRTlast (h)

Control

4.9

5.2

5.5

0.497

BRD

4.4

5.1

5.8

Tmax (h)

Control

4.0

4.0

4.0

0.192

BRD

2.0

4.0

4.0

Vz/F (L)

Control

2.9

4.3

7.2

0.905

BRD

3.1

4.0

6.7

  1. *PK-parameters area under the curve from the time of dosing extrapolated to infinity (AUCinf), area under the curve from the time of dosing to the last sampling time point (AUC0~48), area under the curve from the time of dosing to the last measurable positive concentration (AUClast), area under the first moment curve extrapolated to infinity (AUMCinf), area under the first moment curve from dosing to the last measurable concentration (AUMClast), apparent clearance (CL/F), maximum observed concentration (Cmax), mean residence time from the time of dosing to the last measurable concentration (MRTlast), time to the maximum concentration (Tmax), terminal half-life (T1/2λz), elimination rate (λz), and apparent volume of distribution associated with the terminal phase (Vz/F). Groups control—healthy control calves, and BRD—M. haemolytica infected calves.
  2. **Mann–Whitney test was used to compare the difference between the control and BRD groups.
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