Table 6 The fecal pharmacokinetics of ciprofloxacin in calves administered enrofloxacin subcutaneously (low dose 7.5 mg/kg, high dose 12.5 mg/kg body weight, 14 animals in each healthy and BRD combined group) computed by a non-compartmental model (i.e., statistical moments) analysis.
Parameters* | Group | Minimum | Median | Maximum | Adjusted P-value** |
|---|---|---|---|---|---|
AUCinf (h × μg/mL) | High | 381 | 424 | 467 | 0.533 |
Low | 325 | 375 | 426 | ||
AUCinf/Dose | High | 31 | 34 | 37 | 0.267 |
Low | 43 | 50 | 57 | ||
AUC0~48 (h × μg/mL) | High | 371 | 398 | 425 | 0.050 |
Low | 316 | 355 | 395 | ||
AUClast (h × μg/mL) | High | 371 | 384 | 398 | 0.035 |
Low | 316 | 355 | 395 | ||
AUMClast (h2 × μg/mL) | High | 6846 | 7368 | 7889 | 0.094 |
Low | 6633 | 7483 | 8333 | ||
Cmax (μg/mL) | High | 18.2 | 21.1 | 24.1 | 0.062 |
Low | 13.7 | 18.5 | 23.3 | ||
T1/2 λz (h) | High | 6.4 | 8.4 | 10.5 | NA |
Low | 6.3 | 8.2 | 10.1 | ||
λz (1/h) | High | 0.07 | 0.09 | 0.11 | NA |
Low | 0.07 | 0.09 | 0.11 | ||
MRTinf (h) | High | 22.2 | 22.3 | 22.3 | NA |
Low | 22.0 | 23.1 | 24.1 | ||
MRTlast (h) | High | 17.2 | 19.2 | 21.3 | NA |
Low | 21.0 | 21.1 | 21.1 | ||
Tmax (h) | High | 8.0 | 10.0 | 12.0 | 0.347 |
Low | 12.0 | 12.0 | 12.0 |
