Figure 4 | Scientific Reports

Figure 4

From: Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA)

Figure 4

MR alters metabolic markers more in males. MilliPlex of serum from mice overnight fasted at time of sacrifice. Selected panel results of Insulin (a), (b) and Leptin (c), (d) measured by MilliPlex. Data was log transformed before analysis to preserve normality. Data points at lower end of detection were included as lowest value given by the assay’s internal standard curve. IGF-1 (e), (f) and Adiponectin (g), (h) measured in plasma by ELISA. Analysis was within each sex via Two-Way ANOVA for main effects. Post-hoc analysis was performed with Sidac multiple comparisons correction to assess the diet effect within each genotype. Graphs represent means ± s.d. and all groups were 8–10 mice for MilliPlex, and 5 mice per group for IGF-1 ELISA. (*p < 0.05; **p < 0.01; ***p < 0.001).

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