Table 2 Additive interaction between CNR1’s rs2023239 genotype and child SLEs on the odds of problematic alcohol use (i.e., AUDIT score ≥ 8).

From: The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use

 

 < 1 SLEs

OR (95% CI)

 ≥ 1 SLEs

OR (95% CI)

OR (95% CI) for SLE within strata of genotype

N case/control

N case/control

TT

126/1257

1

53/406

1.08 (0.76, 1.55) p = 0.66

1.1 (0.77, 1.58) p = 0.61

CC and CT

51/557

0.9 (0.63, 1.27) p = 0.53

33 / 160

1.81 (1.16, 2.83) p ≤ 0.01

1.99 (1.18, 3.34) p ≤ 0.01

ORs (95% CI) for genotype within strata of SLEs

 

0.89 (0.63, 1.27) p = 0.53

 

1.67 (1.01, 2.74) p = 0.04

 
  1. Case/control refers to problematic alcohol use (yes/no).
  2. OR Odds Ratios, CI Confidence Interval, SLE Stressful life event.
  3. Estimates adjusted for age, sex, and diagnosis of anxiety or depression.
  4. Crude RERI estimate 0.84 (95% CI: − 0.05–1.74; p = 0.07).
  5. Adjusted RERI estimate 0.83 (95% CI: 0.0–1.67; p = 0.05), calculated with values from table above: 1.81 − 0.9 − 1.08 + 1 = 0.83.
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