Table 3 Summary of the neuronal activities in the somatosensory cortex before, 30 min, and 2 h after administration.

From: Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides

High-AUC group

Low-AUC group

 

Frequency (Hz)

Amplitude (ΔF/F0)

C.C. of paired neuron

 

Frequency (Hz)

Amplitude (ΔF/F0)

C.C. of paired neuron

Acetamiprid (n = 4)

Pre

0.0248 ± 0.0010

3.40 ± 0.16

0.410 ± 0.0052

Pre

0.0278 ± 0.0024

2.67 ± 0.20

0.152 ± 0.0037

30 min

0.0279 ± 0.0026 (p = 0.9510)

2.74 ± 0.17 (p = 0.0032)

0.310 ± 0.0066 (p < 0.0001)

30 min

0.0321 ± 0.0038 (p = 0.2532)

2.57 ± 0.18 (p = 0.8956)

0.223 ± 0.0052 (p < 0.0001)

2 h

0.0299 ± 0.0018 (p = 0.1150)

2.83 ± 0.20 (p = 0.0077)

0.289 ± 0.0059 (p < 0.0001)

2 h

0.0335 ± 0.0027 (p = 0.0356)

2.53 ± 0.19 (p = 0.7071)

0.222 ± 0.0045 (p < 0.0001)

Nicotine (low dose) (n = 4)

Pre

0.0258 ± 0.0015

3.10 ± 0.45

0.367 ± 0.014

Pre

0.0286 ± 0.0019

2.06 ± 0.27

0.136 ± 0.0065

30 min

0.0223 ± 0.0015 (p = 0.264)

2.66 ± 0.42 (p = 0.5537)

0.294 ± 0.016 (p < 0.0001)

30 min

0.0302 ± 0.0038 (p = 0.6864)

2.75 ± 0.44 (p = 0.1544)

0.201 ± 0.013 (p = 0.0037)

2 h

0.0299 ± 0.0028 (p = 0.6713)

3.06 ± 0.48 (p = 0.9991)

0.246 ± 0.013 (p < 0.0001)

2 h

0.0330 ± 0.0023 (p = 0.5248)

2.43 ± 0.39 (p = 0.8624)

0.177 ± 0.010 (p = 0.0102)

Nicotine (high dose) (n = 3)

Pre

0.0301 ± 0.0015

3.65 ± 0.26

0.354 ± 0.0049

Pre

0.0309 ± 0.0021

2.32 ± 0.18

0.113 ± 0.0026

30 min

0.0303 ± 0.0018 (p = 0.9761)

4.15 ± 0.40 (p = 0.9245)

0.264 ± 0.0068 (p < 0.0001)

30 min

0.0312 ± 0.0020 (p = 0.9197)

3.04 ± 0.24 (p = 0.0431)

0.215 ± 0.0059 (p < 0.0001)

2 h

0.0277 ± 0.0020 (p = 0.2190)

3.44 ± 0.27 (p = 0.6009)

0.266 ± 0.0067 (p < 0.0001)

2 h

0.0275 ± 0.0019 (p = 0.2850)

2.63 ± 0.23 (p = 0.6657)

0.209 ± 0.0065 (p < 0.0001)

  1. Abbreviations: AUC area under the curve, C.C. cross-correlation, min minutes, h hour.
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