Figure 5
From: AXL inhibition improves BRAF-targeted treatment in melanoma
Apoptosis induction in melanoma cells following combined inhibition of AXL and BRAF. Melmet 1 and A375 cells were treated with 2 µM BRAFi, 2 µM AXLi or a combination of both, DMSO for control for 48 h, stained with Hoechst (a) or annexin-V (b) and analyzed by flow cytometry. Insert in (b) represents the % of annexin-V positive Melmet 1 cells from three independent biological experiments. Average ± SEM, n = 3. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.
