Figure 4 | Scientific Reports

Figure 4

From: Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor

Figure 4The alternative text for this image may have been generated using AI.

Inhibition of exportin 1 leads to nuclear retention of P101L PNKP. Stably-transfected PNKP-knockout HeLa cells expressing GFP-tagged wild-type and mutant PNKP were treated with leptomycin B (LMB) for 3 h and then stained with DAPI and imaged at 40 × magnification.

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