Table 3 Comparison of toxicity grade between UHF and BT.

From: Comparison of toxicities between ultrahypofractionated radiotherapy versus brachytherapy with or without external beam radiotherapy for clinically localized prostate cancer

Grade

UHF

Subgroup of UHF

BT ± EBRT

Subgroup of BT ± EBRT

p-value*

L-UHF

H-UHF

HDR + EBRT

LDR

LDR + EBRT

( n = 253)

(%)

(n = 162)

(%)

(n = 91)

(%)

(n = 1664)

(%)

(n = 1187)

(%)

(n = 411)

(%)

(n = 66)

(%)

 

(a) Acute toxicity

Gastrointestinal No. (%)

0

185

(73%)

146

(90%)

39

(43%)

1477

(89%)

1060

(89%)

369

(90%)

48

(73%)

 < 0.001

1

55

(22%)

14

(9%)

41

(45%)

181

(11%)

123

(10%)

42

(10%)

16

(24%)

 

2

13

(5%)

2

(1%)

11

(12%)

5

(0.3%)

3

(0.3%)

0

(0%)

2

(3%)

 

3

0

(0%)

0

(0%)

0

(0%)

1

(0.1%)

1

(0.1%)

0

(0%)

0

(0%)

 

Genitourinary No. (%)

0

126

(50%)

99

(61%)

27

(30%)

470

(28%)

347

(29%)

33

(8%)

4

(6%)

 

1

93

(37%)

43

(27%)

50

(55%)

865

(52%)

632

(53%)

204

(50%)

30

(45%)

 < 0.001

2

34

(13%)

20

(12%)

14

(15%)

324

(19%)

119

(10%)

173

(42%)

32

(48%)

 

3

0

(0%)

0

(0%)

0

(0%)

5

(0.3%)

4

(0.3%)

1

(0.1%)

0

(0%)

 

(b) Late toxicity

Gastrointestinal No. (%)

0

206

(81%)

151

(93%)

55

(60%)

1419

(85%)

993

(83%)

378

(92%)

48

(73%)

0.0181

1

36

(14%)

9

(6%)

27

(30%)

207

(12%)

163

(14%)

29

(7%)

15

(23%)

 

2

9

(4%)

2

(1%)

7

(8%)

37

(2%)

30

(3%)

4

(1%)

3

(5%)

 

3

2

(1%)

0

(0%)

2

(2%)

1

(0.1%)

1

(0.1%)

0

(0%)

0

(0%)

 

Genitourinary No. (%)

0

170

(67%)

131

(81%)

39

(43%)

728

(44%)

534

(45%)

169

(41%)

25

(38%)

 < 0.001

1

69

(27%)

27

(17%)

42

(46%)

671

(40%)

473

(40%)

168

(41%)

30

(45%)

 

2

13

(5%)

4

(2%)

9

(10%)

158

(9%)

105

(9%)

69

(17%)

11

(17%)

 

3

1

(0.1%)

0

(0%)

1

(1%)

80

(5%)

75

(6%)

5

(1%)

0

(0%)

 
  1. BT brachytherapy, EBRT external beam radiotherapy, UHF ultrahypofractionated radiotherapy, HDR high-dose-rate, LDR low-dose-rate, L-UHF low dose UHF EQD2 < 100 Gy1.5 (α/β = 1.5), H-UHF high dose UHF EQD2 ≥ 100 Gy1.5 (α/β = 1.5), GU genitourinary, GI gastrointestinal.
  2. *p-value was calculated between UHF and BT ± EBRT.
Back to article page