Table 5 Toxicity comparison among subgroup Patients characteristics between and BT with or without external beam radiotherapy.

From: Comparison of toxicities between ultrahypofractionated radiotherapy versus brachytherapy with or without external beam radiotherapy for clinically localized prostate cancer

Group

UHF

BT ± EBRT

Subgroup (Accumulated incidence at 5-years) (PT NO)

L-UHF

H-UHF

HDR + EBRT

LDR

LDR + EBRT

(1.2%)

(9.3%)

(1.5%)

(0.3%)

(2.4%)

(n = 162)

(n = 91)

(n = 1187)

(n = 411)

(n = 66)

(a) Gastrointestinal oxcicity

L-UHF

0.0281

1

0.0725

1

H-UHF

-

 < 0.001

 < 0.001

 < 0.001

HDR + EBRT

0.0771

1

LDR

0.0891

LDR + EBRT

Group

UHF

BT ± EBRT

Subgroup (Accumulated incidence at 5-years) (PT NO)

L-UHF

H-UHF

HDR + EBRT

LDR

LDR + EBRT

(3.0%)

(11.1%)

(13.5%)

(13.5%)

(13.4%)

(n = 162)

(n = 91)

(n = 1187)

(n = 411)

(n = 66)

(b) Genitourinary toxicity

L-UHF

0.069

0.171

0.069

0.812

H-UHF

1

1

1

HDR + EBRT

1

1

LDR

1

LDR + EBRT

  1. Bold values indicate statistically significance.
  2. BT brachytherapy, HDR high-dose-rate, LDR low-dose-rate, EBRT external beam radiotherapy, UHF ultrahypofractionated radiotherapy, L-UHF low dose UHF EQD2 < 100 Gy1.5 (α/β = 1.5), H-UHF high dose UHF EQD2 ≥ 100 Gy1.5 (α/β = 1.5).
  3. *p-value was calculated between UHF and BT ± EBRT.