Figure 2 | Scientific Reports

Figure 2

From: Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as β-lactamase inhibitors

Figure 2

Ribbon plot of the overall structure of CTX-M-14. The active site region is highlighted by a surface representation and the active site residues and covalently bound Bortezomib/Ixazomib is shown as sticks (A). The close-up of the active site region (B) reveals the hydrogen bonding network among the active site residues. The covalently bound inhibitors are super positioned and shown in sticks with C-atoms colored in cyan and yellow for Bortezomib and Ixazomib, respectively. The corresponding Fo—Fc polder omit maps of the inhibitors in complex with the refined models of CTX-M-14 are shown in light green and contoured at 3σ (C and D).

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