Table 1 Sentinel variants in eight regions significantly associated with moderate-to-severe asthma risk in this GWAS of 3181 cases and 3590 controls (OR = odds ratio for coded allele, SE = standard error, PDE = p-value for the differential effects test, RAF = risk allele frequency for AMD and RA controls, respectively).

From: A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk

SNP

CHR

BP (GRCh38)

Nearest gene

Risk/non-risk allele

OR

SE

P-value

PDE

RAFcase

RAFcontrol

rs139210940

2

102,265,885

IL1RL2

AT/A

1.339

0.051

8.08 × 10–9

0.333

0.879

0.847, 0.843

rs10455025

5

111,069,301

TSLP

C/A

1.304

0.037

4.36 × 10–13

0.856

0.387

0.34, 0.326

rs17205170

6

32,634,706

HLA-DQA1

G/T

1.449

0.046

7.92 × 10–16

0.168

0.84

0.797, 0.779

rs2875584

6

90,240,909

BACH2

C/T

1.238

0.038

1.57 × 10–8

0.351

0.706

0.666, 0.653

rs7130588

11

76,559,639

C11orf30

G/A

1.242

0.036

2.46 × 10–9

0.04

0.386

0.358, 0.332

rs2104047

14

68,287,700

RAD51B

T/C

1.245

0.039

1.28 × 10–8

0.134

0.312

0.262, 0.274

rs11631778

15

71,314,041

THSD4

G/A

1.225

0.037

3.54 × 10–8

0.436

0.354

0.305, 0.311

rs7216558

17

39,913,818

GSDMB

T/C

1.263

0.035

1.91 × 10–11

0.442

0.545

0.479, 0.494

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