Figure 8 | Scientific Reports

Figure 8

From: Characterization of aging tumor microenvironment with drawing implications in predicting the prognosis and immunotherapy response in low-grade gliomas

Figure 8

Validation of ATMERS. (a,b) Kaplan–Meier survival analysis (a) and time-dependent ROC curves (b) of aging TME score in the validation cohort from CGGA database (DataSet ID: mRNAseq_325). (c,d) Similar results obtained in the merged validation cohort from GEO database (GSE4271, GSE4412, GSE43378 and GSE84010). (e) Kaplan–Meier survival analysis between low and high aging TME score groups in IMvigor210 cohort. (f) Proportion of anti-PD-L1 therapeutic response in low and high aging TME score groups in IMvigor210 cohort. (g) Comparison of ageing TME scores between patients with different anti-PD-L1 therapeutic response in IMvigor210 cohort. (h–k) Identification of unfavorable ATMERS in immunohistochemistry staining. (l) Determination of unfavorable ATMERS using western blot analysis in which lane 1 represented normal brain tissues, lane 2, 3 represented LGG tissues in grade II, lane 4, 5 and 6 represented LGG tissues in grade III. ATMERS, aging tumor microenvironment related signature; ROC, receiver operating characteristic; AUC, area under curves; TME, tumor microenvironment; LGG, low-grade glioma, CR/PR: complete response/partial response; PD/SD: progressed/stable disease.

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