Table 4 Univariate regression analysis and multivariate regression analysis for PFS before PSM.

From: The efficacy of drug-eluting bead or conventional transarterial chemoembolization plus apatinib for hepatocellular carcinoma with portal vein tumor thrombus

Characteristics

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Age (years)

0.998 (0.983, 1.014)

0.834

  

ALT (U/L)

1.004 (1.000, 1.007)

0.027

0.997 (0.993, 1.001)

0.137

Leukocyte (109/L)

1.125 (1.039, 1.219)

0.004

1.070 (0.984, 1.165)

0.114

Lymphocytes (109/L)

0.742 (0.528, 1.043)

0.086

  

Platelet (109/L)

1.001 (0.999, 1.003)

0.201

  

Tumor size (cm)

1.055 (1.016, 1.095)

0.005

1.005 (0.966, 1.047)

0.800

Gender

0.187

  

Male

1

   

Female

0.717 (0.437, 1.176)

   

HBV infection

0.418

  

Yes

1

   

No

0.819 (0.504, 1.329)

   

Cirrhosis

0.429

  

Yes

1

   

No

1.160 (0.803, 1.675)

   

TACE session

 < 0.001

 

0.001

Once

1

 

1

 

Multiple

0.198 (0.122, 0.322)

 

0.397 (0.229, 2.869)

 

Portal invasion

 < 0.001

 

0.005

VP1–VP2

1

 

1

 

VP3–VP4

2.759 (1.889, 4.029)

 

1.855 (1.200, 2.869)

 

Tumor number

 

0.636

  

1

1

   

 ≥ 2

0.919 (0.646, 1.306)

   

Extrahepatic metastases

0.084

  

Yes

1

   

No

0.733 (0.514, 1.043)

   

AFP level

0.074

  

 < 200 (ug/L)

1

   

 ≥ 200 (ug/L)

1.403 (0.968, 2.034)

   

Child–Pugh

 < 0.001

 

0.747

A

1

 

1

 

B

2.181 (1.457, 3.263)

 

1.081 (0.672, 1.740)

 

ECOG

0

1

 

1

 

1

3.322 (2.076, 5.316)

 < 0.001

3.083 (1.850, 5.135)

 < 0.001

2

7.222 (4.255, 12.257)

 < 0.001

6.976 (3.731, 13.044)

 < 0.001

Treatment

0.002

  

D-TACE-A

1

 

1

 

C-TACE-A

0.559 (0.389, 0.804)

 

0.402 (0.270, 0.600)

 < 0.001

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