Table 2 MIC of antibiotics for E. coli and P. aeruginosa in the presence of CPP-PNAs.

From: Scaffold size-dependent effect on the enhanced uptake of antibiotics and other compounds by Escherichia coli and Pseudomonas aeruginosa

E. coli

Antibiotics

KFF-NC MIC (μg/mL)

KFF-bamB MIC (μg/mL)

KFF-tolC MIC (μg/mL)

KFF-bamB KFF-tolC MIC (μg/mL)a

 

Vancomycin

100

> 200

100

100

 

Actinomycin D

50

25

50

< 6.3

 

Novobiocin

12.5

0.8

12.5

< 0.4

 

Fusidic acid

50

12.5

50

< 0.4

 

5-Ketoclomazone

> 250

> 250

125

62.5

 

P. aeruginosa

Antibiotics

Control (no CPP-PNA) MIC (μg/mL)

RXR-NC MIC (μg/mL)

RXR-bamB MIC (μg/mL)

RXR-oprM MIC (μg/mL)

RXR-bamB RXR-oprM MIC (μg/mL)b

Vancomycin

1024

1024

256

512

256

Erythromycin

128

128

32

64

< 16

Carbenicillin

64

64

8

32

< 4

  1. CPP-PNAs were added at the concentration of 5 and 3 μM for E. coli and P. aeruginosa, respectively.
  2. aIn the presence of both CPP-PNAs, equimolar KFF-bamB and KFF-tolC were mixed.
  3. bIn the presence of both CPP-PNAs, equimolar RXR-bamB and RXR-oprM were mixed.
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