Table 2 Univariable and multivariable Cox proportional hazards analyses of patient demographic, clinicopathologic, and treatment factors, with overall survival AS outcome.
N (%) | Univariable analyses | Multivariable analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |||||
Patient characteristics | ||||||||||
Age at diagnosis | < 40 | 36 (22) | Ref | – | – | – | – | – | ||
41–65 | 78 (48) | 1.27 | 0.43–4.57 | 0.68 | ||||||
> 65 | 49 (30) | 1.41 | 0.44–5.27 | 0.57 | ||||||
Sex | Male | 84 (52) | Ref | – | – | – | – | – | ||
Female | 79 (48) | 0.73 | 0.31–1.67 | 0.46 | ||||||
Race/ethnicity | White | 113 (69) | Ref | – | – | – | – | – | ||
Black | 17 (10) | 0.94 | 0.15–3.41 | 0.93 | ||||||
Hispanic | 24 (15) | 2.19 | 0.77–5.56 | 0.13 | ||||||
Other | 9 (6) | 2.79 | 0.43–10.2 | 0.24 | ||||||
Insurance | Private | 92 (56) | Ref | – | – | – | – | – | ||
Medicare | 48 (29) | 0.95 | 0.05–4.80 | 0.96 | ||||||
Medicaid | 8 (5) | 0.99 | 0.37–2.43 | 0.99 | ||||||
Other | 15 (9) | 0.84 | 0.13–3.03 | 0.81 | ||||||
Charlson comorbidities | None | 131 (80) | Ref | – | – | – | – | – | ||
1 | 24 (15) | 1.13 | 0.32–3.06 | 0.83 | ||||||
≥ 2 | 8 (5) | 1.78 | 0.28–6.22 | 0.47 | ||||||
Clinicopathologic characteristics | ||||||||||
Site | Stomach | 103 (63) | Ref | – | – | Ref | – | – | ||
Small intestine | 60 (37) | 2.40 | 1.05–5.62 | 0.038 | 2.72 | 1.13–6.69 | 0.026 | |||
Tumor size | ≤ 5 cm | 52 (32) | Ref | – | – | Ref | – | – | ||
> 5 cm | 84 (52) | 5.49 | 1.57–34.6 | 0.0050 | 3.42 | 0.90–22.5 | 0.073 | |||
Tx | 27 (17) | 7.29 | 1.39–53.6 | 0.019 | 4.45 | 0.79–34.3 | 0.091 | |||
Mitoses | ≤ 5 per 50 HPF | 108 (66) | Ref | – | – | Ref | – | – | ||
> 5 per 50 HPF | 36 (22) | 5.62 | 2.26–15.1 | < 0.001 | 4.77 | 1.86–13.2 | 0.0012 | |||
Unspecified | 19 (12) | 4.05 | 1.06–13.5 | 0.042 | 3.59 | 0.92–12.2 | 0.064 | |||
Multifocality | Absent | 121 (74) | Ref | – | – | – | – | – | ||
Present | 30 (18) | 1.15 | 0.38–2.92 | 0.78 | ||||||
Unspecified | 12 (7) | 0.66 | 0.04–3.21 | 0.67 | ||||||
Node status | Negative | 58 (36) | Ref | – | – | – | – | – | ||
Positive | 11 (7) | 0.95 | 0.15–3.55 | 0.95 | ||||||
Unknown | 94 (58) | 0.56 | 0.23–1.32 | 0.18 | ||||||
Metastasis at diagnosis | Absent | 144 (88) | Ref | – | – | – | – | – | ||
Present | 19 (12) | 0.81 | 0.13–2.76 | 0.77 | ||||||
Treatment characteristics | ||||||||||
Margins | Negative | 125 (77) | Ref | – | – | – | – | – | ||
Positive | 10 (6) | 2.87 | 0.66–8.81 | 0.14 | ||||||
Unknown | 9 (6) | 3.00 | 0.69–9.21 | 0.13 | ||||||
Not performed | 19 (12) | 1.76 | 0.41–5.40 | 0.40 | ||||||
Systemic therapy | None given | 77 (47) | Ref | – | – | Ref | – | – | ||
Given | 84 (52) | 3.15 | 1.25–9.60 | 0.014 | 1.66 | 0.63–5.27 | 0.32 | |||
Unknown | 2 (1) | 5.83 | 0.30–36.3 | 0.19 | 1.83 | 0.09–13.4 | 0.62 | |||
