Figure 6 | Scientific Reports

Figure 6

From: Aryl hydrocarbon receptor and Krüppel like factor 10 mediate a transcriptional axis modulating immune homeostasis in mosquitoes

Figure 6

KLF10 is mediating immunomodulation downstream of AhR. (A) The Kyn-mediated immune suppression was reversed by dsAhR and dsKLF10, shown by the survival post bacterial challenge. (B) qPCR results of the genes in the dsAhR or dsKLF10 cohorts. (C) The effect of dsAhR and dsKLF10 on the survival of mosquitoes in which the IMD was overactivated by dsCaspar, no bacterial challenge was given. No significant difference was observed when dsCaspar + dsGFP was compared to dsGFP (Mantel–Cox test, P > 0.05). The survival was reduced in the co-silencing mosquitoes (Mantel–Cox test, P < 0.001). Each line represents pooled data from 5 cohorts with standard error bars.

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