Figure 1

A thyroid nodule, assigned to Bethesda category III, was considered malignant diagnosed by the combination of TIRADS and BRAFV600E analysis. The nodule proved to be a malignant tumour confirmed by postoperative pathology. (a), the 2D sonogram classified as TIRADS 4b, (b), mutant BRAFV600E gene, (c), papillary thyroid carcinoma.