Table 2 Results of sex-specific analysis and sex-SNP interaction analysis of PICALM variant rs3851179 in the ADGC.

From: Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Sex-stratified resultsa

Beta

Std error

p-value

MAF

Male model 1

 − 0.206

0.035

5.62E−09

0.358

Male model 2

 − 0.176

0.038

4.08E−06

0.359

Female model 1

 − 0.083

0.029

4.37E−03

0.354

Female model 2

 − 0.087

0.031

5.60E−03

0.352

Interaction resultsb

Interaction beta

Std error

p-value

MAF

Model 1

0.116

0.044

8.05E−03

0.354

Model 2

0.372

0.048

7.84E−02

0.354

  1. N = 9135 cases (60% female), 9,677 controls (60% female).
  2. aModel 1: adjusted for age, sex, and PCs; Model 2: adjusted for age, sex, PCs, and APOE genotype.
  3. bModel 1: adjusted for age and PCs; Model 2: adjusted for age, PCs, and APOE.
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