Table 1 Significant upstream regulators in inflammatory skin diseases.

From: Integrated bioinformatic analysis of gene expression profiling data to identify combinatorial biomarkers in inflammatory skin disease

 

Upstream regulators

Molecules

Z-score

P value

AD

CNR1

GPCR

2.714

1.09E−05

BMP4

Growth factor

2.431

6.23E−04

AMH

Growth factor

2.181

1.10E−04

CDK4/6

group

2

3.97E−02

KE

BMP4

Growth factor

2.887

2.15E−05

CNR1

GPCR

2.496

2.64E−05

GH1

Growth factor

2.433

7.32E−02

AMH

Growth factor

2.385

6.30E−05

BMP2

Growth factor

2.357

2.28E−04

TNFSF15

Cytokine

2.213

2.45E−04

CCR2

GPCR

2.2

1.48E−01

EDN1

cytokine

2.152

7.70E−03

Li

BMP4

Growth factor

2.942

7.51E−06

IL15

Cytokine

2.449

3.18E−03

BMP2

Growth factor

2.406

2.76E−03

Jnk

Group

2.397

7.08E−05

CNR1

GPCR

2.35

4.40E−07

IL7

Cytokine

2.296

2.58E−03

CDK4/6

Group

2.236

3.04E−02

AMH

Growth factor

2.181

4.53E−04

TNFRSF8

Transmembrane receptor

2.164

1.38E−02

Pkc(s)

group

2.132

8.48E−03

Pso

CNR1

GPCR

2.496

1.27E−04

BMP4

Growth factor

2.3

4.16E−04

CAV1

Transmembrane receptor

2.216

7.95E−02

  1. AD; atopic dermatitis, KE; contact eczema, Li; lichen planus, Pso; psoriasis vulgaris, GPCR; G protein-coupled receptor.
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