Figure 2 | Scientific Reports

Figure 2

From: Melatonin reduces the endoplasmic reticulum stress and polyubiquitinated protein accumulation induced by repeated anesthesia exposure in Caenorhabditis elegans

Figure 2

Expression of genes related to the unfolded protein response and endoplasmic reticulum-associated protein degradation pathways. (A) Increased ire-1 expression followed by repeated isoflurane exposure was suppressed by melatonin treatment. Luzindole attenuated the effect of melatonin on the level of ire-1. (B) The expression of sel-1, sel-11, cdc-48.1, and cdc-48.2 was significantly decreased after repeated isoflurane exposure. While the differences in sel-1, cdc-48.1, and cdc-48.2 expression were still significant between the control-melatonin and the isoflurane-melatonin groups, sel-11 expression was comparable between the two groups. All batches included three plates in each group, and the same assay was performed three times. Error bar, standard deviation; *P < 0.05; N.S., not significant.

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