Figure 7
From: Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors
Enrichment analysis of the related genes of PIK3R1 and PIK3R2. (A) Heatmap indicated the relationship between PIK3R1 expression and PIK3R2 expression in tumor signaling. Analysis through the TIMER 2.0 (http://timer.cistrome.org/database). (B) The protein interaction network of 52 genes. These 52 genes were obtained from STRING tool (https://string-db.org/) and the protein interaction network was modified by Cytoscape 3.9.1 software (https://cytoscape.org/). Color nodes represent identified proteins, and colorful bands with different widths represent the degree of interaction between nodes. The darker the color, the stronger the interaction. (C) The most highly enriched items of KEGG pathway of the related genes of PIK3R1 and PIK3R2. The most highly enriched items of BP (D), CC (E), MF (F) of the related genes of PIK3R1 and PIK3R2 in head and neck cancer. The functional enrichment of genes interacting with PIK3R1 and PIK3R2 by the analysis of GO and KEGG by DAVID tools (https://david.ncifcrf.gov) and then the results were visualized with R 4.0.5 (https://www.r-project.org/).
