Figure 3 | Scientific Reports

Figure 3

From: Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A2A receptor signaling

Figure 3

Stimulation of A2A AdoRs reduced the basal and TNFα-induced MMP-3 expression by MH7A cells. Activation of A2A receptors suppressed constitutive expression of MMP-3 mRNA in MH7A cells. Cells were incubated for 24 h with the indicated concentration of HENECA, and MMP-3 mRNA levels estimated by RT-PCR. Experiments were repeated three times, and data are presented as the mean ± SD. ★p < 0.05 and ★★p < 0.01 vs. 0 μM HENECA.

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