Figure 2

Violin plots of Spike S1 immunoglobulin G (IgG) concentrations by number of COVID-19 vaccine doses, SARS-CoV-2 infection history and vaccine brand (A) and in SARS-CoV-2-naïve adults at two to four months following a completed Comirnaty schedule by age group (B). Triangles and black horizontal lines represent median concentrations of IgG to Spike S1 in BAU/mL. The dashed horizontal line represents the threshold for seropositivity. In (A) IgG measurements were taken between two weeks and two months after the indicated dose; while in (B) between two and four months after completion of the Comirnaty schedule. Wilcoxon-Mann–Whitney tests were used to test for differences in IgG concentrations by infection history in (A) with blocking for strata of sex, and by age group in (B) with blocking for strata of sex and time since second dose (less versus more than three months). * p < 0.05; ** p < 0.01; *** p < 0.001; NS: not significant (p > 0.100); BAU/mL: binding antibody units per mL; IgG: immunoglobulin G.