Table 2 The association between NLRP3 gene polymorphisms and CKD.

From: Combined effects of nucleotide-binding domain-like receptor protein 3 polymorphisms and environmental metals exposure on chronic kidney disease

NLRP3 genotypes

CKD ases

Controls

Age-sex adjusted

ORs (95% CI)

Multivariate adjusted

ORs (95% CI)a

rs4925654 G>A

GG

159 (73.27)

303 (71.13)

1.00

1.00§

GA

54 (24.88)

113 (26.53)

0.90 (0.62–1.32)

0.72 (0.46–1.14)

AA

4 (1.84)

10 (2.35)

0.75 (0.23–2.43)

0.36 (0.08–1.51)

GA/AA versus GG

58 (26.73)

123 (28.87)

0.88 (0.62–1.25)

0.70 (0.45–1.08)

rs4925650 G>A

GG

59 (27.06)

133 (31.44)

1.00§

1.00§

GA

101 (48.52)

210 (49.65)

1.08 (0.73–1.59)

1.37 (0.87–2.16)

AA

58 (21.53)

80 (18.91)

1.62 (1.02–2.56)*

1.96 (1.15–3.34)*

GA/AA versus GG

159 (72.94)

290 (68.56)

1.23 (0.85–1.77)

1.54 (1.01–2.36)*

rs12239046 C>T

CC

70 (32.11)

166 (38.88)

1.00

1.00

CT

114 (52.29)

189 (44.26)

1.45 (1.01–2.09)*

1.77 (1.16–2.73)**

TT

34 (15.60)

72 (18.86)

1.12 (0.68–1.84)

1.10 (0.62–1.96)

CT/TT versus CC

148 (67.89)

261 (61.12)

1.36 (0.96–1.92)+

1.56 (1.04–2.34)*

rs4925648 C>T

CC

124 (56.88)

234 (54.80)

1.00

1.00

CT

78 (35.78)

162 (37.94)

0.92 (0.65–1.30)

0.94 (0.62–1.41)

TT

16 (7.34)

31 (7.26)

0.98 (0.52–1.87)

0.98 (0.47–2.04)

CT/TT versus CC

94 (43.12)

193 (45.20)

0.93 (0.67–1.29)

0.95 (0.64–1.39)

rs10925025 G>A

AA

70 (31.94)

165 (38.73)

1.00

1.00

AG

113 (52.07)

189 (44.37)

1.43 (0.99–2.06)+

1.77 (1.15–2.72)**

GG

34 (15.67)

72 (16.90)

1.12 (0.68–1.83)

1.10 (0.62–1.95)

AG/GG versus AA

147 (67.74)

261 (61.27)

1.34 (0.95–1.90)+

1.56 (1.04–2.33)*

rs10925019 C>T

CC

102 (46.79)

199 (46.60)

1.00

1.00

CT

101 (46.33)

182 (42.62)

1.09 (0.77–1.53)

0.98 (0.65–1.46)

TT

15 (6.89)

46 (10.77)

0.64 (0.34–1.20)

0.78 (0.38–1.61)

CC/CT versus TT

203 (93.12)

381 (89.23)

0.62 (0.34–1.13)

0.79 (0.40–1.59)

rs1539019 C>A

CC

72 (33.03)

166 (39.06)

1.00

1.00

CA

113 (51.83)

189 (44.47)

1.40 (0.97–2.01)+

1.76 (1.15–2.71)**

AA

33 (15.14)

70 (16.47)

1.09 (0.66–1.79)

1.09 (0.61–1.96)

CA/AA versus CC

146 (66.97)

259 (60.94)

1.31 (0.93–1.85)

1.56 (1.04–2.33)*

rs3806265 T>C

TT

68 (31.19)

111 (26.06)

1.00

1.00

TC

108 (49.54)

215 (50.47)

0.79 (0.51–1.24)

0.79 (0.51–1.24)

CC

42 (19.27)

100 (23.47)

0.70 (0.41–1.19)

0.70 (0.41–1.19)

TC/CC versus TT

150 (68.81)

315 (73.94)

0.76 (0.50–1.16)

0.76 (0.50–1.16)

rs10925026 A>C

CC

70 (32.11)

166 (39.06)

1.00

1.00

CA

114 (52.29)

187 (44.00)

0.83 (0.56–1.21)

1.79 (1.16–2.74)**

AA

34 (15.60)

72 (16.94)

0.69 (0.43–1.11)

1.10 (0.62–1.95)

CA/AA versus CC

148 (68.35)

259 (60.94)

0.79 (0.55–1.13)

1.57 (1.05–2.35)*

rs10157379 T>C

CC

69 (31.65)

164 (38.68)

1.00

1.00

CT

114 (52.29)

189 (44.58)

1.45 (1.01–2.10)*

1.79 (1.16–2.75)**

TT

35 (16.06)

71 (16.75)

1.18 (0.72–1.93)

1.15 (0.65–2.04)

CT/TT versus CC

149 (68.35)

259 (60.94)

1.38 (0.97–1.95)+

1.59 (1.05–2.38)*

rs12143966 A>G

GG

57 (26.15)

125 (29.83)

1.00

1.00

GA

112 (51.38)

191 (45.58)

1.29 (0.87–1.95)

1.41 (0.89–2.21)

AA

49 (22.48)

103 (24.58)

1.04 (0.66–1.66)

1.14 (0.67–1.96)

GA/AA versus GG

161 (73.85)

294 (70.17)

1.20 (0.83–1.74)

1.31 (0.86–2.01)

rs10754555 C>G

CC

85 (38.99)

154 (36.15)

1.00

1.00

CG

102 (46.79)

199 (46.71)

0.93 (0.65–1.35)

0.87 (0.57–1.32)

GG

31 (14.22)

73 (17.14)

0.78 (0.47–1.28)

0.69 (0.39–1.23)

CG/GG versus CC

133 (61.01)

271 (63.85)

0.89 (0.64–1.15)

0.82 (0.55–1.21)

rs3806268 A>G

AA

68 (31.19)

113 (26.59)

1.00

1.00

AG

108 (49.54)

212 (49.88)

0.85 (0.58–1.25)

0.84 (0.54–1.31)

GG

42 (19.27)

100 (23.53)

0.71 (0.44–1.13)

0.73 (0.43–1.26)

AG/GG versus AA

150 (68.81)

312 (73.41)

0.81 (0.56–1.15)

0.80 (0.53–1.22)

rs12048215 A>G

AA

103 (47.25)

192 (44.96)

1.00

1.00

AG

93 (42.66)

185 (43.33)

0.94 (0.67–1.33)

0.93 (0.62–1.41)

GG

22 (10.09)

50 (11.71)

0.83 (0.47–1.44)

0.95 (0.50–1.77)

AG/GG versus AA

115 (52.75)

235 (55.02)

0.92 (0.66–1.28)

0.94 (0.64–1.38)

  1. NLRP3 rs3806265 and rs10754555 were missing for one participant. NLRP3 rs4925654, rs10925025, rs1539019, rs10925026, and rs3806268 were missing for two participants. NLRP3 rs10157379 was missing for three participants. NLRP3 rs4925650 was missing for four participants. NLRP3 rs12143966 was missing for nine participants.
  2. CKD chronic kidney disease, NLRP3 nucleotide-binding domain-like receptors 3, OR odds ratio, CI confidence interval.
  3. +0.05 ≤ p < 0.1, *p < 0.05, **p < 0.01.
  4. §p < 0.05 for the trend test.
  5. aAdjusted for age, sex, educational level, alcohol, coffee and tea consumption, analgesic usage, and disease histories of diabetes and hypertension.
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