Figure 2
From: Temporal reproducibility of IgG and IgM autoantibodies in serum from healthy women
Heatmap of IgM autoantibodies, log2 transformed (left) and quantile normalized (right) (n = 7,242 with CV < 20%) IgM autoantibody profiling using HuProt arrays of repeat samples collected one year apart from n = 46 heathy subjects (n = 92 samples total). Raw log2 transformed data (a) and quantile normalized data (right) was used to cluster AAbs and samples using pearson distance higherarchical clustering for 7,242 probes with CV < 20%. Top bar annotation colors correspond to individual subjects. (Two samples from each subject clustered together for all 46 subjects using both log2 transformed data and quantile normalized data).
